Medical neurotechnology
Deep-sleep neurostimulation in early Alzheimer’s disease
Elevvo is a patented closed-loop auditory stimulation device intended to modulate slow-wave activity during sleep in patients with mild cognitive impairment due to Alzheimer’s disease.
- Deep-sleep stimulation
- Overnight use at home
- Remote clinical supervision
Clinical programme
Five clinical studies since 2022
In collaboration with
Phase 2a · Nana-Lab
Efficacy in improving declarative memory in early Alzheimer’s disease
Randomised, cross-over, double-blind, placebo-controlled trial in 37 patients with mild cognitive impairment due to Alzheimer’s disease with an amnestic phenotype. Elevvo significantly increased slow-wave amplitude and was associated with improved declarative memory versus placebo.
Declarative memory
More word pairs remembered after the night
Mean word-pair retention. Significant difference versus placebo, p = 0.04.
Mechanism
Larger slow waves during stimulation
Median slow-wave amplitude on the stimulation night versus the placebo night. Significant difference versus placebo, p < 10⁻⁶.
Full results of the Nana-Lab trial
Read the preprint on medRxiv →Professional contact
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